You know... I was a little concerned that Omni Brain wasn't edgy enough with that G rating. After all we talk about drugs and sex ... well... all the time! So I went back and checked the rating site again to see if were just having a clean fluke here at Omni Brain. Thankfully we're up to an R rating... perfect!

Today starts a new series that I perhaps blatantly stole from Shelley over at Retrospectacle but It's such a darn great idea! From the mouth of Shelley:
Pretty much I'm just going to dig back into the forgotten and moldering annuls of scientific publications to find weird and interesting studies that very likely would never be published or done today (and perhaps never should have.)Clearly I'm not doing the same thing but her idea gave me one of my own. We here at Omni Brain will be digging into classic media coverage of all things science (usually brain related - clearly). I have a feeling most things will be from the NY Times since they are archived very very well all the way back into the 19th century. But if I can find it online or you can point me in the right direction any media source will be fair game. So without further ado here's our first entry into the world of....Pseudoscience in the Press of the Past
When Psychology, Anthropology, Physiognomy and Phrenology were uttered as equals in the same sentence.
From the NY Times Classifieds March 5, 1864:

P.S. I think we'll do this series on Mondays (I have another one already scheduled) and they will always be in the History Category if you'd like to find the whole series in the archives.
Thanks to Vaughan over at Mind Hacks we've discovered that the great movie, The Brain That Wouldn't Die is now in the public domain :) You can watch it below the fold or even download it in full right here or here. This movie is a wonderful wonderful movie! ... ok really. I've never seen it nor do I think I'll take the time to watch it unless I'm really bored. But you should! let us know how it is. It is after all about brains!
Here's the plot summary from imdb:
After a car crash, a man keeps his wife's head alive in his laboratory. As if this weren't enough, an evil beast pounds and screams from a locked room adjacent to the lab. Written by Sam Volchenboum {volcs@mayo.edu}Read the rest of this post... | Read the comments on this post...The unethical surgeon Dr. Bill Cortner (Herb Evers) is developing a technique of transplantation of organs and members using a serum against rejection. When he has a car accident with his girlfriend Jan Compton (Virginia Leith), he saves her head only, and tries to find a woman with a beautiful body to transplant Jan's head against her will. Written by Claudio Carvalho, Rio de Janeiro, Brazil
Brilliant but borderline psychotic surgeon does secretive, experimental work with limb transplants and tissue rejection drugs, much to the chagrin of his surgeon-father. When he crashes his car and his fiancee is decapitated, his research - far from complete - is put to the test. His focus then becomes finding an appropriate donor body to make his fiancee whole, while the current and failed experiments in his basement laboratory grow restless. Written by Alan Brewster {radiobrewster@yahoo.com}
Chuck Palahniuk's latest novel Rant is, first of all, not a rant. It's the fictional oral history of Buster "Rant" Casey, a fearless antihero who enjoys poisonous spider and snake bites yet loves his mom. Though not as creepy as previous novels like the self-injury splatterfest Haunted, or as intense as Fight Club, the story is sprayed with gore and gross-outs. Every time Rant sticks his arm into a hole in the ground or hides dozens of spiders in his jumpsuit and waits to be bitten, I cringe.
Influenced by sci-fi concepts from Aldous Huxley, William Gibson and J.G. Ballard's fetishistic Crash, Palahniuk makes them his own with twists venturing into the supernatural and neuroscientific. When I began reading I wondered how my review might fit with Omni Brain's focus on brain sciences, but I was soon cheered with descriptions of brain jacks and rabies infections in the central nervous system. "Out-cording" is the recording of someone's full sensory experience, a "neural transcription" sold as mass-market entertainment. A "boosted peak" is an out-cording filtered through the sharper senses of a German Shepherd or a baby's unsullied nervous system. But even those boosts grow tiresome to an audience of the not-so-distant future.
What I adore about Palahniuk is his lush imagination. Just as contemporary films are more violent and pr0n is more extreme than a decade or two ago, this novel jabs to revive dulled senses but is more successful than formulaic slasher flicks. It's not easy to shock but there are some jolts encountered by his thrillseeking characters. At the same time, Graphic Traffic reports on car accidents (with details from paramedics) are treated as mundane. Snotballs also play an important role in the plot.
Rant joins a group of boredom chasers called the Party Crashers, who hunt each other's cars in a cross between slam dancing and bumper cars without bumpers. Jaded by boosted peaks, they fester in an underclass of citizens of the night in an engineered society divided by curfews between night and day. Alienation leads to polarization in an overpopulated world. Crack-of-dawn-risers disdain night-dwellers as lazy and "other," and that bigotry fuels a violent class war.
Rant's personal quest for immortality also spreads an epidemic of rabies. Part vampire, part zombie, rabies-infected people lunge at and bite others in turn. The infected are mostly nighttimers, who become targets for daytimers. Parents disown children and cops shoot to kill as the sun rises. With crisis comes climax.
Rant goes out in a high-speed chase with multiple crashes and a flaming Christmas tree on the roof of his car. His final words, broadcast on Graphic Traffic as he screeches off a cliff, "What if reality is nothing but some disease?"
Just how much is society a construction of neurobiology? The novel teases with descriptions of plagues and viruses affecting the brain before asking that question. With Rant's departure and an unusual method of screwing with genetics, it seems possible to escape both the past and the future.
Read the comments on this post...Does your politician suffer from Chronic Re-Election Paranoia (CREEP)? Do you think our nation has an Incarcerex dependence? Tell your elected officials to give up the quick fix and create a new bottom line for the war on drugs.
More information here.
Read the comments on this post...Videos of student robot projects from U of Alberta's PSYCO 403X1 Research in Cognitive Science. Here's an answer to the burning question, "Do robots prefer Pepsi over Coke?"
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A sweet design from someone who seems to be familiar with the work of Helen Fisher, neuroanthropologist of love:
Ever been in love? If so, you know what it feels like to have a lot of the neurotransmitter dopamine. This design brings together two symbols of love: a traditional heart and a dopamine molecule. Express your girly nerd!Read the comments on this post...
Well... I'm not sure if you all noticed... but my posting has been lacking lately. It's been for a great reason though. I'm on vacation in the Florida Keys. Beaches, boats, and leather skin ;)
We saw a great water spout the other day - of course my cell phone picture didn't turn out but this picture I found on the internet is nearly exactly what we saw. Pretty cool eh?

A waterspout is an intense columnar vortex (usually appearing as a funnel-shaped cloud) that occurs over a body of water and is connected to a cumuliform cloud. In the common form, it is a nonsupercell tornado over water, and brings the water upward. Also, it is weaker than most of its land counterparts.
Via Bora of NC-17 rated A Blog Around The Clock. Omni Brain is G-rated? Maybe we need to spice things up...
Hmm, well, Vaughan at Mind Hacks has been writing about autoerotic sex deaths, most recently involving a man who constructed a complex full-body plastic bag. More links to studies (many include NSFW pictures, most require subscription but some older articles are free) below the cut:
Read the rest of this post... | Read the comments on this post...In the new blog Crappy Graphs, which is not really crappy, Brian's come up with a depiction of coolness in social media.

In I-was-going-to-write-about-this-months-ago news, The Scientist magazine profiled The Amygdaloids: Scientists Who Rock Out:
With a serious air about him, New York University neuroscientist Joe LeDoux takes hold of a microphone to introduce the first song, about "one of the great enigmas in the history of civilization" -- the mind-body problem.The Amygdaloids -- whose name is a play on the amygdala, an oval structure in the brain's temporal lobe involved in emotional behavior -- are a band comprised of LeDoux and NYU biologist Tyler Volk on guitar and vocals, NYU neural science postdoctoral student Daniela Schiller on drums, and Schiller's research assistant, Nina Galbraith Curley, on bass. Their "gimmick," says LeDoux, is that all of their original songs are about science.
"Mind Body Problem" is reminiscent of the Eagles and Bob Dylan -- easygoing classic rock that makes people in the audience tap their feet. "My body wants you so, but my mind just says no," LeDoux sings. At the end of the song, Volk, consistently the most energetic, throws his arms in the air, yelling to the audience in reference to the song's title: "Did that solve it for you!?"
Watch the band in videos at their web page, including a show a Madison Square Gardens complete with The Wave.
More seriously, check out the LeDoux Laboratory's research on emotions and memory. There's also a good NIH lecture video online.
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A Swedish man has been granted disability benefits due to an "addiction" to heavy metal music. Playing in two bands, including Silverland, he also attended nearly 300 concerts last year.
Tullgren says he has always had difficulty holding down a job, mainly because he is absent most of the time.Psychologists decided Tullgren's obsession is nothing less than an addiction, which puts him in a difficult situation in the labour market. Tullgren said he has been fighting for recognition for a long time.
Many occupational psychologists in Sweden, however, are totally baffled by the decision. "If somebody has a gambling addiction, we don't send them down to the racetrack. We try to cure the addiction," [said] deputy employment director Henrietta Stein.
Benefits include part of his salary as a dishwasher, and accomodation from his boss to play loud music. Rock on!
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Seriously!
According to the BBC News:
Drinking coffee protects against an eyelid spasm that can lead to blindness, a study suggests.
Italian researchers looked at the coffee drinking and smoking habits of 166 people with blepharospasm.
Sufferers have uncontrollable twitching of the eyelid which, in extreme cases, stops them being able to see.
One or two cups of coffee a day seemed to reduce the risk of the condition, the team reported in the Journal of Neurology, Neurosurgery and Psychiatry.
Not that I've ever heard of blepharospasm ;) It is a great disease name though - I'll give you that!
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Ahh... some great research from Spain. You know when you get home from vacation you really need another vacation to get ready to go back to work. Well... it's called Post-Holiday Syndrome.
Here's the whole mess from Eurekalerts:
Millions of people will leave their working places and start their holidays in the next weeks. The daily routine will be part of the past and resting days, pictures at the seashore and summer memories will be back to stay - at least for some weeks.Experts estimate that 35 per cent of Spanish workers between the ages of 25 and 40 will have to face the "post-holiday syndrome" when they get back to routine: a general feeling of discomfort caused by the person's inability to adapt to work after finishing holidays.
This past weekend I went to RoboGames. There were many squee moments (PLEN was there! so cute! etc.), many pictures taken (which are trapped on my phone for the moment), and many things learned while wandering around among the room full of dads and their kids.
Maybe the most important lesson was that although some robots are designed with nice goals like helping the elderly, mixing cocktails or enabling the paralysed to walk, what the crowd was most interested in was watching robots tear each other apart in combat. I'm not sure what this says about humanity - or me, since I admit to cheering when they crashed into each other and parts went flying. At least I had a conversation with an engineer about cognitive robotics as well (he wasn't applying it though). And observed that a good way for artists to make money nowadays is to make their creations coin-operated.
More later, when I get my photos, but here's a pic from the web site of the superheavyweights (300 lbs or so) in combat. Yay robots!
Read the comments on this post...I need a new phone and it just so happens that the new iPhone is coming out very soon. So the question is...

Feel free to leave comments telling me why not to buy it as well ;)
Read the comments on this post...This is a wonderful idea!
Swizzle sticks and carbon nanotubes don't usually share the same room, but they're both on the menu for Eugene's first Science Pub.Part of an international phenomenon that's been going on almost 10 years, Science Pub brings top researchers out of their labs and into bars and coffee shops to give people a street-level look at cutting-edge research. It makes its Eugene debut at 7 tonight at downtown night spot Luna with a talk by University of Oregon chemistry professor and nanoscience researcher Jim Hutchison.
The idea is that the big ideas in science are a little easier to digest with a pint or a martini to wash them down. The big idea Hutchison will bring to the bar is nanotechnology, which at least sounds as if it might go well with a microbrew.

HT: Enrique Gili
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Ok.. just kidding but they did create a resolution denying that humans were to blame for global warming. I'm glad we have religious figures as well as the government to interpret our scientific data! What would we do without them? I'm about to send in a paper in an attempt to get it published. I'm a little confused now on who to send it to first! Do I send it to the Baptists or to the Bush administration? Oh... or are they the same thing? I'm so confused can someone help me out here?
Here's some of the global warming story.
Southern Baptists approved a resolution on global warming Wednesday that questions the prevailing scientific belief that humans are largely to blame for the phenomenon and also warns that increased regulation of greenhouse gases will hurt the poor.
ohh.. and here's some more juicy stupidity.
The SBC resolution, approved near the end of the denomination's annual meeting, acknowledges a rise in global temperatures. But it rejects government-mandated limits on carbon-dioxide and other emissions as "very dangerous" because they might not make much difference and could lead to "major economic hardships" worldwide.Originally, the measure also backed more government-funded research into global warming's causes and alternative energies to oil. But the resolution was amended to drop that language, in part over concerns that it would endorse strong government engagement in the issue.
If you haven't seen it yet, everyone's raving about The Neurophilosopher's excellent post about the history of trepanation. Trepanning creates a hole in the skull; cultures have done it for a variety of superstitious reasons over the ages.
I've wanted to do a (far more brief) post on the subject myself, since it's begging for more debunking. Self-trepanning advocate Bart Hughes claims that trepanation induces higher states of consciousness by increasing blood volume in the brain and decreasing cerebrospinal fluid. Increased vitality, etc.
This about that: trepanning can't affect blood flow or volume inside the brain since the hole doesn't penetrate the dura mater. It's not physically possible. CSF is located in the subarachnoid layer, below the dura (see figure; click for larger image). Mr. Hughes and his followers only opened their skulls.
It's also quite unnecessary if all you want is more blood flow in the brain. A quote from The Neurocritic: "There are a lot of ways you can increase blood flow to the brain. One of them is raising your metabolic rate, you don't need to drill a f***ing hole in your head. Like, duh."
It doesn't make one smarter, younger or happier anyway. One man who underwent a home procedure only to conclude it didn't work warns, "I would, at this time, warn against undergoing this procedure, mostly to anyone who was considering this as a way to alleviate chronic depression. If someone underwent this hoping it would be a panacea for all of their troubles and then it wasn't, that might just push them off the edge." He adds, "As much I hate to realize it, I believed what I wanted to believe."
For an interesting look at the contemporary subculture around trepanation, and his story, complete with diary and gory pictures, check out this page at the fab BME body modifications site.
Read the comments on this post...Joke of the Day from Professor Vinod Menon, about a George Bush brain scan.
Read the comments on this post... Offered on eBay:
ThoughtVertising - A Global Advertising FirstFor the first time in advertising history, brand owners are offered the opportunity to buy media space within someone's mind.
"How?" I will think of your brand every hour, on the hour, for a period of a week.
That's all, he thinks about a brand hourly, and submits a report after a week of "sponsoring brainwaves." A joke? Maybe, but the serious winning bid was $10,000. [And I'm helping make it worth that.] See more. Via Media Blog.
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Brad of Milligram wrote about a psychiatrist from olden days who claimed he could diagnose patients by their smell alone, and expressed scepticism (wouldn't you?), but there actually is some science behind it.
Identification of schizophrenic patients by examination of body odor using gas chromatography-mass spectrometry and a cross-selective gas sensor array, Di Natale et al., 2005 (free PDF) has the scoop on the "richer" and "peculiar" scent. They concluded that there is no one variable, but a "global variant" of body odor.
I imagine that a practising psychiatrist with a good nose just might be able to sniff out a diagnosis, at least a first impression.
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"Pavlov's Cockroach: Classical Conditioning of Salivation in an Insect," sounds like a great paper and seriously...salivation in the cockroach! that's great stuff ;)
But this is certainly not the first time classical conditioning has been demonstrated in other animals. Heck, Eric Kandel (among others) won the Nobel prize for his work on classical conditioning and learning in Aplysia (sea slugs). If you're really excited about the salivation component of Classical Conditioning here's a little summary from Medical News Today :)

A new study, led by Makoto Mizunami and colleagues at Tohoku University in Japan, demonstrates classical conditioning of salivation in cockroaches, for the first time in species other than dogs and humans, and its underlying neural mechanisms remain elusive because of the complexity of the mammalian brain. This study demonstrates, for the first time, classical conditioning of salivation in species other than dogs and humans, thereby providing the first evidence of sophisticated neural control of autonomic function in insects. The results provide a useful model system for studying cellular basis of conditioning of salivation in the simpler nervous system of insects.
And luckily... this paper was published in PLoS ONE so it's free to all!
Watanabe H, Mizunami M (2007)
Pavlov's Cockroach: Classical Conditioning of Salivation in an Insect
PLoS ONE 2(6): e529. doi:10.1371/journal.pone.0000529
And finally... the moral of the story.... with this new information I now know I can train Cockroaches to play ping pong like these cats!
Ever see a rat tickled? You can now - and evidently they laugh :)
[via scienceblog]
Here's another video of rats playing with their owner. I knew they could be friendly but this is something new to me. I didn't know that they could have so much personality - I was pretty sure they just crept around sewers or sat in a nest all day.
Top Ten Annoyances to People with Bipolar Disorder
10. Free unsolicited pharmacological advice from everyone met.
9. Bi-Polar gratuitous hyphenation. It's not two words!
8. Scars on wrists ending dreams of career as hand model.
7. Endless personal stories about side effects in support groups and forums. They can already see you're fat.
6. Manic irritability.
5. Credit card bills from buying a dozen pairs of shoes at once.
4. Hypersexuality is a good thing, keep your outdated morals to yourself.
3. Positive recovery wellness self-determination Pollyannaism.
2. Unfinished past manic projects strewn about blocking path to door.
1. Stigma. That's not funny.
Ok this is just ridiculous! I understand nerve agents but a gay bomb? You gotta love what the freedom of information act and the creative minds that brought you such projects as MKULTRA can do when brought together.
As part of a military effort to develop non-lethal weapons, the proposal suggested, "One distasteful but completely non-lethal example would be strong aphrodisiacs, especially if the chemical also caused homosexual behavior."The documents show the Air Force lab asked for $7.5 million to develop such a chemical weapon.
"The Ohio Air Force lab proposed that a bomb be developed that contained a chemical that would cause enemy soliders to become gay, and to have their units break down because all their soldiers became irresistably attractive to one another," Hammond said after reviwing the documents.
"The notion was that a chemical that would probably be pleasant in the human body in low quantities could be identified, and by virtue of either breathing or having their skin exposed to this chemical, the notion was that soliders would become gay," explained Hammond.
Really?! Are you guys over there at CBS 5 sure this isn't a prank? Well probably not since It seems that the BBC broke the story a few years ago. Here's their original story.
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We all know, thanks to Dan Simons and Chris Chabris (unless you've been living under a rock), that if we're really paying attention to something we can miss something else entirely... like a gorilla walking into the middle of a room and banging on its chest. Check out the video here, clearly this won't work for you now since you know what to look for but there are some other examples on Dan Simons' site that you can check out as well.
In any case ... on to the main story here which is really the complete opposite of Inattentional Blindness. This time the Gorilla suit was meant to bring as much attention as possible to a great cause. Here's a snippet from the San Francisco Chronicle:
The Holubs were among more than 400 people who turned out for the first Great Gorilla Run through Golden Gate Park. The 4.3-mile race, which began shortly after 9 a.m., was billed as good fun for a good cause: The Gorilla Organization, which sponsored the race, was established under a different name nearly 30 years ago to save endangered gorillas in Africa. There are only about 700 mountain gorillas left in the wild, the organization says.The event started in London in 2003 and has raised about $2 million. The San Francisco gorilla run was the organization's first such event in the United States. The number of runners was limited to just over 400 because the organization ran out of gorilla suits -- provided with the $100 entry fee.
Jillian Miller, executive director of the Gorilla Organization, which was inspired by the work of the late American primatologist Dian Fossey, took in the spectacle of people dressed as their closest living relatives. Smiling, she said, "What is it about gorilla costumes that make people so happy?"

Worst science headline: Brain 'Pacemaker' Tickles Your Happy Nerve --Wired, writing on vague nerve stimulators. Though "brain pacemaker" is a commonly used term to describe neurostimulator implants, "happy nerve" to describe the vagus is just silly.
Best science headline (journal) Why obesity is the new smoking. --Nursing Standard, on why obesity has complicated patient care
Yes yes... I know cancer isn't funny and I also seem to be obsessed with Family Guy in the last day or two. So without further ado.... Here's a Peter Tumor!
I know you probably can't see the image and text very well - so just go ahead and click on the picture for this damn funny parody in full size.

Clearly I'm not a medicine bio person - but this just had to make it onto the blog.
Researchers at Burnham Institute for Medical Research ("Burnham") have provided the first evidence that gamma-secretase, an enzyme key to the progression of Alzheimer's, acts as a tumor suppressor by altering the pathway of epidermal growth factor receptor (EGFR), a potential treatment target for cancer. Expedited to publication online by Proceedings of the National Academy of Sciences, these findings reveal a limitation of targeting gamma-secretase for treatment of Alzheimer's and potentially other diseases.[source]Amyloid precursor protein (APP) is found inside all cells. Though its function is unknown, it is associated with Alzheimer's in the following way. APP can be cleaved by the enzymes beta-secretase and gamma-secretase, sequentially. Upon gamma-secretase cleavage, amyloid-beta (AB) peptides are dispelled into the extracellular matrix region and eventually aggregate into senile plaques, characteristic of Alzheimer's.
Residing inside cells, gamma-secretase is a complex of four proteins, including a family of proteins known as the presenilins (PS). Mutations in PS are found in approximately 5% of individuals suffering Alzheimer's, resulting in early onset of the disease.
At the center of the activities governing AB production is gamma-secretase, the subject of intensive interest as a potential therapy target for Alzheimer's. Mice deficient in PS/gamma-secretase activity tend to develop skin cancer. EGFR is known to be upregulated in a variety of tumors, including various skin cancers. Elevated EGFR levels in tumors are linked with poor clinical prognosis and tumor resistance to chemotherapy. EGFR is therefore the subject of intensive investigation by pharmaceutical companies as a potential treatment target for cancer.
Are there any other diseases that have contributed as directly to the treatment of another? (ok... I know this hasn't practically contributed to the treatment of brain tumors yet... but you get the point and hopefully soon it will!)
And if you don't recognize the picture... It's a brain tumor from Family Guy :)
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I'm going to make a bold bold prediction right here on Omni Brain. With the announcement of wireless electricity there will soon be a group of crazed wackjobs protesting it (well.. that is if it ever actually makes it to the consumer level) because the electricity flowing through the air causes Cancer, Autism, Genital Warts, or something else silly. Yes yes.. you've heard it first right here on Omni Brain!
Here's some of the details from BBC News:
US researchers have successfully tested an experimental system to deliver power to devices without the need for wires.
The setup, reported in the journal Science, made a 60W light bulb glow from a distance of 2m (7ft).
WiTricity, as it is called, exploits simple physics and could be adapted to charge other devices such as laptops.
And here's a bit more in depth description from the MIT Press release:
Read the rest of this post... | Read the comments on this post..."The Brain of Morbius". Doctor Who challenges an increasingly unstable Morbius to a mind-bending contest. Enjoy ;)
Read the comments on this post...An oldie but goodie starring I dream of Jeannie as God ... Enjoy!
Here's Ned Flanders dealing with an Evolution exhibit.
And here's the evolution vs. creationism debate starring Lisa
Ahh Press Releases.... Don't you just love it when someone who doesn't know anything about science or really even give a shit either comes up with extremely inane or obvious titles?
This time around the titles are come from good ol' EurekAlert.
Our first title falls under the duh category:
"Brain holds clues to bipolar disorder"
Ohh.... Reaalllly? As opposed to what?!
Our second title falls under the "my cousins uncles brothers step-sisters boss's foot surgeons dogs breeders groomers friend" category.
"Lack of sun does not explain low vitamin D in elderly who are overweight"
I feel like they're forgetting another way of classifying this sort of person. Perhaps... old, overweight, smoker who eats pork rinds at tea time.
Channel N: Vintage Online Neuroimaging includes clips like this 1998 overlay of PET onto MRI, depicting pain in an area of the brain. View file.
Can dogs perform deduction? Evidently so...

The provocative new experiment indicated that dogs can do something that previously only humans, including infants, have been shown capable of doing: decide how to imitate a behavior based on the specific circumstances in which the action takes place.
This week's multimedia presentation is made of animated gifs. Yep, images that [should] play on all computer systems, of brain scans rendered in small animated .gif files (around 1 mb each, 4 mb for the larger orthogonal slices with three views). Artist/scientist/research assistant Mark Dow created these mesmerizing animations along with some earlier Quicktime animations; visit his page for more. 
Above: Human brain, three orthogonal T1 weighted MRI slice sets.

Left: saggital T1 weighted MRI slices. Right: coronal T1 weighted MRI slices.
Thank you for permissions, Mark! Make more? Fly-ins and spinning brains are beautiful (even if, as Steve said, not everyone is into 'real' science). Also check out Mark's Brain art fodder page; more on that later.
Read the comments on this post...If you're totally not into 'real' science - here's some brand spanking new Nessie footage. Proof the he really does exist! Clearly...
And another (clearer) video can be found here.
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I Q Mind Brain Memory Self Help Library.

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